{"id":93206,"date":"2018-01-24T07:47:21","date_gmt":"2018-01-24T11:47:21","guid":{"rendered":"https:\/\/stateofthenation2012.com\/?p=93206"},"modified":"2018-01-24T07:59:20","modified_gmt":"2018-01-24T11:59:20","slug":"scientists-discover-huge-amounts-of-aluminum-in-the-brains-of-deceased-autistic-people","status":"publish","type":"post","link":"https:\/\/stateofthenation2012.com\/?p=93206","title":{"rendered":"Scientists Discover Huge Amounts of Aluminum In The Brains of Deceased Autistic People"},"content":{"rendered":"<p><!--more--><a href=\"https:\/\/stateofthenation2012.com\/wp-content\/uploads\/2018\/01\/aluminum-brain-autism.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-93212\" src=\"https:\/\/stateofthenation2012.com\/wp-content\/uploads\/2018\/01\/aluminum-brain-autism.jpg\" alt=\"\" width=\"640\" height=\"352\" srcset=\"https:\/\/stateofthenation2012.com\/wp-content\/uploads\/2018\/01\/aluminum-brain-autism.jpg 759w, https:\/\/stateofthenation2012.com\/wp-content\/uploads\/2018\/01\/aluminum-brain-autism-300x165.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><\/p>\n<p>Scientists have been aware of aluminum\u2019s neurotoxicity for <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/963531\" target=\"_blank\" rel=\"noopener\">decades<\/a>.<\/p>\n<p><i>by\u00a0<a href=\"http:\/\/www.collective-evolution.com\/2018\/01\/16\/scientists-discover-huge-amounts-of-aluminum-in-the-brains-of-deceased-autistic-people\/\" target=\"_blank\" rel=\"noopener\">Robert F. Kennedy Jr.<\/a><\/i><\/p>\n<p>Although aluminum\u2019s apologists have tried to shroud the metal\u2019s risks in manufactured\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21157018\" target=\"_blank\" rel=\"noopener\">controversy<\/a>, a growing number of reports by researchers in the\u00a0<a href=\"http:\/\/content.iospress.com\/download\/journal-of-alzheimers-disease-reports\/adr170010?id=journal-of-alzheimers-disease-reports%2Fadr170010\" target=\"_blank\" rel=\"noopener\">United Kingdom<\/a>,\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4318414\/\" target=\"_blank\" rel=\"noopener\">France<\/a>,\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23609067\" target=\"_blank\" rel=\"noopener\">Canada<\/a>,\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26275795\" target=\"_blank\" rel=\"noopener\">Israel<\/a>, the\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5596046\/\" target=\"_blank\" rel=\"noopener\">U.S.<\/a>and elsewhere has furnished substantive evidence linking aluminum to neuropathology, including the epidemics of\u00a0<a href=\"http:\/\/humansarefree.com\/search\/label\/Alzheimer%27s\" target=\"_blank\" rel=\"nofollow noopener\">Alzheimer\u2019s disease<\/a>\u00a0(AD) and\u00a0<a href=\"http:\/\/humansarefree.com\/2016\/04\/italian-courts-rule-vaccines-cause.html\" target=\"_blank\" rel=\"nofollow noopener\">autism spectrum disorder<\/a>\u00a0(ASD).<\/p>\n<p>Aluminum levels were particularly high in the male brains, including in a 15-year-old boy with ASD who had the study\u2019s single highest brain aluminum measurement.<\/p>\n<div class=\"separator\"><\/div>\n<p><a name=\"more\"><\/a><a href=\"http:\/\/amzn.to\/2rhSNm3\" target=\"_blank\" rel=\"noopener\"><b>Dr. Christopher Exley<\/b><\/a>\u00a0\u2014 one of the world\u2019s leading experts on aluminum toxicity \u2014 has shown that\u00a0<a href=\"http:\/\/content.iospress.com\/download\/journal-of-alzheimers-disease-reports\/adr170010?id=journal-of-alzheimers-disease-reports%2Fadr170010\" target=\"_blank\" rel=\"noopener\">chronic intoxication<\/a>\u00a0with\u00a0<a href=\"http:\/\/www.futsci.com\/uploads\/project\/file\/f004582d987d2142ba418d26149d258d64e024e9.pdf\" target=\"_blank\" rel=\"noopener\">myriad forms<\/a>\u00a0of this \u201cubiquitous and omnipresent metal\u201d is exacting a high price on human health.<\/p>\n<p>Dr. Exley and other aluminum experts such as molecular biologist Dr. Lucija Tomljenovic have confirmed that aluminum readily and actively traverses the blood-brain barrier to\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21157018\" target=\"_blank\" rel=\"noopener\">selectively accumulate<\/a>\u00a0in brain tissues, where it induces unwelcome changes in brain biochemistry.<\/p>\n<p>As Dr. Exley has noted, \u201cThere are no \u2018normal\u2019 levels of brain aluminum,\u201d meaning that \u201cits presence in brain tissue,\u00a0<i>at any level<\/i>, could be construed as\u00a0<a href=\"http:\/\/www.futsci.com\/uploads\/project\/file\/f004582d987d2142ba418d26149d258d64e024e9.pdf\" target=\"_blank\" rel=\"noopener\">abnormal<\/a>\u201d [emphasis added].<\/p>\n<p>Below is a video of him speaking on his study.<\/p>\n<p>http:\/\/youtu.be\/SmkVv8pcVhc<\/p>\n<p>Documenting Aluminum in the ASD Brain<\/p>\n<p>In light of the fact that even\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21157018\" target=\"_blank\" rel=\"noopener\">minute<\/a>\u00a0amounts of aluminum can have adverse neurological consequences, Dr. Exley\u2019s newest\u00a0<a href=\"http:\/\/worldmercuryproject.org\/wp-content\/uploads\/Mold-2017-Aluminum-in-Brain-Tissue-and-Autism.pdf\" target=\"_blank\" rel=\"noopener\">paper<\/a>\u00a0\u2014 which reports on the first-ever study of aluminum in ASD brain tissue \u2014 is groundbreaking.<\/p>\n<p>Published in the Journal of Trace Elements in Medicine and Biology, the paper documents some of the highest values for aluminum in human brain tissue ever recorded. Using a two-pronged study design (see box), the researchers measured and characterized aluminum deposits in brain tissues from five to ten ASD donors, most of whom died in their teens or twenties.<\/p>\n<p><b>Study DesignQuantitative component:\u00a0<\/b>First, the investigators used graphite furnace atomic absorption spectrometry (<a href=\"http:\/\/www.calpoly.edu\/~acensull\/Chem439\/GFAAS.html\" target=\"_blank\" rel=\"noopener\">GRAAS<\/a>) to measure aluminum content in frozen brain tissue samples.<\/p>\n<p>Frozen tissue was available from one female donor (age 44) and four male donors (ages 15, 22, 33 and 50) who, when alive, had a confirmed ASD diagnosis. The researchers quantified aluminum levels in 59 tissue samples representing five different areas of the brain (frontal, parietal, occipital, temporal and hippocampal).<\/p>\n<p><b>Qualitative component:<\/b>\u00a0Using a technique called\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4711767\/\" target=\"_blank\" rel=\"noopener\">fluorescence microscopy<\/a>, the researchers visualized aluminum deposits according to their presence (a) insideversus outside the brain cells and (b) in the two types of brain tissue (grey matterversus white matter).<\/p>\n<p>For this component, fixed tissue samples were available for the same five donors plus an additional five donors diagnosed with ASD, including two females (ages 13 and 29) and three males (ages 14, 22 and 29).<\/p>\n<p>What the research team found was startling. The study\u2019s quantitative arm documented \u201cconsistently high\u201d aluminum levels representing \u201csome of the highest values for brain aluminum content ever measured in healthy or diseased tissues.\u201d Specifically:<\/p>\n<ul>\n<li>All five individuals had at least one brain tissue with a \u201cpathologically significant\u201d level of aluminum, defined as greater than or equal to 3.00 micrograms per gram of dry brain weight (\u03bcg\/g dry wt). (Dr. Exley and colleagues developed categories to classify aluminum-related pathology after conducting\u00a0<a href=\"http:\/\/pubs.rsc.org\/en\/content\/articlehtml\/2012\/mt\/c1mt00139f\" target=\"_blank\" rel=\"noopener\">other<\/a>\u00a0brain studies, wherein older adults who died healthy had less than 1 \u03bcg\/g dry wt of brain aluminum.)<\/li>\n<li>Roughly two-thirds (67%) of all the tissue samples displayed a pathologically significant aluminum content.<\/li>\n<li>Aluminum levels were particularly high in the male brains, including in a 15-year-old boy with ASD who had the study\u2019s single highest brain aluminum measurement (22.11 \u03bcg\/g dry wt)\u2014many times higher than the pathologically significant threshold and far greater than levels that might be considered as acceptable even for an aged adult.<\/li>\n<li>Some of the elevated aluminum levels rivaled the very high levels historically reported in victims of\u00a0<a href=\"http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJM197601222940402\" target=\"_blank\" rel=\"noopener\">dialysis encephalopathy syndrome<\/a>\u00a0(a serious iatrogenic disorder resulting from aluminum-containing dialysis solutions).<\/li>\n<\/ul>\n<p><b>The study\u2019s qualitative findings were equally concerning:<\/b><\/p>\n<ul>\n<li>Across the 10 donors, the investigators identified 150 aluminum deposits. All 10 donors had aluminum deposits in at least one tissue.<\/li>\n<li>Aluminum deposits were markedly more prevalent in males than females (129 deposits in seven males, averaging over 18 deposits each, versus 21 deposits in three females, for an average of 7).<\/li>\n<li>In males, most aluminum deposits were inside cells (80\/129), whereas aluminum deposits in females were primarily extracellular (15\/21). The majority of intracellular aluminum was inside non-neuronal cells (microglia and astrocytes).<\/li>\n<li>Aluminum was present in both grey matter (88 deposits) and white matter (62 deposits). (The brain\u2019s grey matter serves to process information, while the white matter provides\u00a0<a href=\"http:\/\/www.dana.org\/Cerebrum\/Default.aspx?id=39152\" target=\"_blank\" rel=\"noopener\">connectivity<\/a>.)<\/li>\n<li>The researchers also identified aluminum-loaded lymphocytes in the meninges (the layers of protective tissue that surround the brain and spinal cord) and in similar inflammatory cells in the vasculature, furnishing evidence of aluminum\u2019s entry into the brain \u201cvia immune cells circulating in the blood and lymph\u201d and perhaps explaining how youth with ASD came to acquire such shockingly high levels of brain aluminum.<\/li>\n<\/ul>\n<p>The Importance of Glial Cells<\/p>\n<p>There are three broad categories of non-neuronal (glial)\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK10869\/\" target=\"_blank\" rel=\"noopener\">cells<\/a>, including astrocytes (which support neuronal signaling), oligodendrocytes (which create myelin) and microglia (responsible for repairing damage). In discussing their results, Dr. Exley\u2019s team comments that the intracellular location of most of the aluminum in these non-neuronal cells was the \u201cstandout observation\u201d for ASD.<\/p>\n<p>\u2026environmental factors can alter microglia function, negatively affecting brain development and synaptic connectivity; when this occurs during important developmental periods, there may be \u2018<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28886007\" target=\"_blank\" rel=\"noopener\">consequences throughout life<\/a>.\u2019<\/p>\n<p>Unlike other brain cells, the\u00a0<a href=\"http:\/\/www.nature.com\/news\/microglia-the-constant-gardeners-1.10732\" target=\"_blank\" rel=\"noopener\">microglia<\/a>\u00a0(which represent about 10% of brain cells) are dedicated immune cells. Microglia also play a key role in the process known as synaptic pruning that takes place during vital phases of cognitive development in early childhood as well as adolescence, continuing into the late 20s.<\/p>\n<p>This process, which some observers have likened to \u201c<a href=\"http:\/\/vanwinkles.com\/what-to-know-about-synaptic-pruning\" target=\"_blank\" rel=\"noopener\">neural spring cleaning<\/a>,\u201d allows the maturing brain to shed \u201c<a href=\"http:\/\/www.nytimes.com\/2016\/01\/28\/health\/schizophrenia-cause-synaptic-pruning-brain-psychiatry.html?rref=collection%2Fsectioncollection%2Fscience&amp;action=click&amp;contentCollection=science&amp;region=rank&amp;module=package&amp;version=highlights&amp;contentPlacement=1&amp;pgtype=sectionfront&amp;_r=0\" target=\"_blank\" rel=\"noopener\">weak or redundant [neuronal] connections<\/a>.\u201d Given this and other important microglial functions, the microglia have attracted considerable research attention as key players in brain disease, including autism.<\/p>\n<p>(Astrocytes also have implications for autism, given the role of astrocyte dysfunction in\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29044647\" target=\"_blank\" rel=\"noopener\">seizures<\/a>\u00a0\u2014 a condition that is frequently\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5618565\/\" target=\"_blank\" rel=\"noopener\">comorbid with ASD<\/a>.)<\/p>\n<p>A pivotal review\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28886007\" target=\"_blank\" rel=\"noopener\">article<\/a>\u00a0published in 2017 observes that \u201cmicroglia are now known to be active participants in brain function and dysfunction\u201d and notes that \u201caberrant [synaptic] pruning during critical developmental periods could contribute to neurodevelopmental disorders.\u201d<\/p>\n<p>Evidence suggesting that the\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28886007\" target=\"_blank\" rel=\"noopener\">microglia are dysfunctional in ASD<\/a>\u00a0includes findings from postmortem ASD brain studies showing \u201caltered microglial counts, morphology, and neuronal interaction\u201d as well as altered expression of microglia-specific genes.<\/p>\n<p>It is clear to many researchers that environmental factors can alter microglia function, negatively affecting brain development and synaptic connectivity; when this occurs during important developmental periods, there may be \u201c<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28886007\" target=\"_blank\" rel=\"noopener\">consequences throughout life<\/a>.\u201d<\/p>\n<p>Aluminum exposure undoubtedly constitutes a dangerous environmental exposure, and Dr. Exley observes that \u201cmicroglia heavily loaded with aluminum\u2026will inevitably be compromised.\u201d<\/p>\n<p>The Most Pervasive Exposure to Aluminum<\/p>\n<p>The study\u2019s results strongly suggest that aluminum is entering the brain in ASD via cells that have become loaded up with aluminum in the periphery. Where is the aluminum coming from? One of the most pervasive routes of modern-day exposure to neurotoxic aluminum is via aluminum adjuvants in vaccines.<\/p>\n<p>(Vaccine manufacturers use aluminum adjuvants to intensify the vaccine recipient\u2019s\u00a0<a href=\"http:\/\/www.cdc.gov\/vaccinesafety\/concerns\/adjuvants.html\" target=\"_blank\" rel=\"noopener\">immune response<\/a>.)<\/p>\n<p><a href=\"http:\/\/www.nature.com\/articles\/srep31578\" target=\"_blank\" rel=\"noopener\">Elsewhere<\/a>, Dr. Exley has described the \u201cmigratory capabilities\u201d of aluminum-based adjuvants \u201cat sites distant to the injection site,\u201d including the brain.<\/p>\n<p>The extreme levels of aluminum found in the brains of the study\u2019s teenage donors have alarming implications for the entire generation of highly aluminum-vaccinated children.<\/p>\n<p>In the ASD brain paper, Dr. Exley and coauthors point out that the \u201cburgeoning\u201d use of aluminum-adjuvant-containing childhood vaccines \u201chas been directly correlated with increasing prevalence of ASD.\u201d<\/p>\n<p>A 2011 study by Lucija Tomljenovic and Christopher Shaw confirms that aluminum-containing vaccines are having crippling neurological consequences.<\/p>\n<p>Their\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22099159\" target=\"_blank\" rel=\"noopener\">analysis<\/a>\u00a0shows that children from countries where ASD prevalence is highest have the highest exposure to aluminum from vaccines; moreover, children\u2019s increased exposure to aluminum adjuvants over the two decades starting in the 1990s significantly correlates with the increase in ASD prevalence in the U.S. Counting the shots now pushed during pregnancy, highly vaccinated American children may receive up to 73 total vaccine doses\u00a0<a href=\"http:\/\/www.healthychildren.org\/English\/safety-prevention\/immunizations\/Documents\/immunizationschedule.pdf\" target=\"_blank\" rel=\"noopener\">by age 18<\/a>, including multiple rounds of\u00a0<a href=\"http:\/\/www.cdc.gov\/vaccines\/pubs\/pinkbook\/downloads\/appendices\/b\/excipient-table-2.pdf\" target=\"_blank\" rel=\"noopener\">injected aluminum<\/a>.<\/p>\n<p><a href=\"https:\/\/stateofthenation2012.com\/wp-content\/uploads\/2018\/01\/US-Vaccines-containing-one-or-more-aluminum-adjuvants.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-93210\" src=\"https:\/\/stateofthenation2012.com\/wp-content\/uploads\/2018\/01\/US-Vaccines-containing-one-or-more-aluminum-adjuvants-934x1024.png\" alt=\"\" width=\"640\" height=\"702\" srcset=\"https:\/\/stateofthenation2012.com\/wp-content\/uploads\/2018\/01\/US-Vaccines-containing-one-or-more-aluminum-adjuvants-934x1024.png 934w, https:\/\/stateofthenation2012.com\/wp-content\/uploads\/2018\/01\/US-Vaccines-containing-one-or-more-aluminum-adjuvants-274x300.png 274w, https:\/\/stateofthenation2012.com\/wp-content\/uploads\/2018\/01\/US-Vaccines-containing-one-or-more-aluminum-adjuvants-768x842.png 768w, https:\/\/stateofthenation2012.com\/wp-content\/uploads\/2018\/01\/US-Vaccines-containing-one-or-more-aluminum-adjuvants.png 1460w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><\/p>\n<div class=\"separator\"><\/div>\n<p>Crucially, Dr. Exley and coauthors note that what \u201cdiscriminates [their] data from other analyses of brain aluminum in other diseases is the age of the ASD donors\u201d [emphasis added].<\/p>\n<p>The extreme levels of aluminum found in the brains of the study\u2019s teenage donors have alarming implications for the entire generation of highly aluminum-vaccinated children.<\/p>\n<p>Moreover, Dr. Exley\u2019s other research has consistently shown that aluminum is the\u00a0<a href=\"http:\/\/www.hippocraticpost.com\/mental-health\/strong-evidence-linking-aluminium-alzheimers\/\" target=\"_blank\" rel=\"noopener\">most significant contributing factor<\/a>\u00a0to Alzheimer\u2019s disease.<\/p>\n<p>Given that it is no longer unheard of to see Alzheimer\u2019s being diagnosed in people who are in their\u00a0<a href=\"http:\/\/www.dailymail.co.uk\/health\/article-2975071\/Early-signs-Alzheimer-s-disease-patients-young-20-Unprecedented-findings-say-disease-eats-away-cells-50-years-symptoms-develop.html\" target=\"_blank\" rel=\"noopener\">20s, 30s, or 40s<\/a>, it is not unreasonable to worry that a catastrophic new wave of AD may be about to compound children\u2019s already heavy burden of ASD and other neurological disorders.<\/p>\n<p>Recognizing the risks, numerous researchers have called for\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5596046\/\" target=\"_blank\" rel=\"noopener\">a halt to the use of aluminum salts in vaccines<\/a>. The powerful results of this study underscore the urgency of heeding this plea as well as eliminating exposure to other sources of neurotoxic aluminum.<\/p>\n<p>___<br \/>\n<a href=\"http:\/\/humansarefree.com\/2018\/01\/scientists-discover-huge-amounts-of.html\">http:\/\/humansarefree.com\/2018\/01\/scientists-discover-huge-amounts-of.html<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-93206","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/stateofthenation2012.com\/index.php?rest_route=\/wp\/v2\/posts\/93206","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stateofthenation2012.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stateofthenation2012.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stateofthenation2012.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stateofthenation2012.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=93206"}],"version-history":[{"count":0,"href":"https:\/\/stateofthenation2012.com\/index.php?rest_route=\/wp\/v2\/posts\/93206\/revisions"}],"wp:attachment":[{"href":"https:\/\/stateofthenation2012.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=93206"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stateofthenation2012.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=93206"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stateofthenation2012.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=93206"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}